The Oddities, Charm, and Suffering of Bipolar Disorder

“Though I am often in the depth of misery, there is still calmness, pure harmony, and music inside me.” —Vincent Van Gogh May is Mental Health Awareness Month, and I’ve […]
When You’re Touched by the Tragedy of Suicide

We celebrated Mother’s Day yesterday. What was it like for you? We truly hope you enjoyed a day of love and hugs as you celebrated with your children. But if […]
Relieving Treatment-Resistant Depression By Treating Metabolic Deficiencies

Originally published in Brain & Behavior Magazine, July 2017 An important discovery has been made at the University of Pittsburgh. It raises the prospect that there may be an entirely new […]
Treating Mood Disorders: Is the Key Hidden in the CSF?

No Wonder Treatment Resistance Has Been Such a Mystery! Clue: Look in the Cerebral Spinal Fluid! A man in his forties, Greg had never experienced life without depression. Treating mood […]
Ketamine Restores Brain Circuitry Damaged by Depression – FAST

In a world where things go wrong and people get sick, every once in awhile something comes along that makes things right again. I’m talking about something that’s so dramatic […]
Behind the Buzz: How Ketamine Changes the Depressed Patient’s Brain

The anesthetic-cum-party drug restores the ability to make connections among brain cells. The Food and Drug Administration’s approval last month of a depression treatment based on ketamine generated headlines, in […]
Cerebral Folate Deficiency and Its Impact on Treatment-Resistance

“If I see far, it’s that I stand on the shoulders of giants.” If you find yourself feeling alone and forgotten in your symptoms, feeling that there’s no one who […]
Low T in Men Causing Your Treatment Resistant Depression..?

Since low testosterone in men has long been presumed to accompany aging, it can be overlooked as a cause of TRD in young men. John had gained 75 lbs (!) […]
Ketamine May Relieve Depression By Repairing Damaged Brain Circuits

Ketamine appears to restore faulty connections between brain cells, according to research performed in mice. The anesthetic ketamine can relieve depression in hours and keep it at bay for a […]
Weekly Ketamine Infusions Show Initial, Repeated Depression Benefits

A new study shows that weekly ketamine infusions are associated with continued and maintained reductions in depressive symptoms among patients with treatment-resistant depression. The findings, which are considered novel among studies […]